Resultado de búsqueda
Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT) family transporters, are found in all aspects of life. Increasing evidence has clarified the molecular mechanism, in which both transporters play critical roles in cellular and physiological functions via mobiliz ….
25 de ago. de 2017 · The lack of high-resolution structure of the ZIPs hinders understanding of the metal transport mechanism. We report two crystal structures of a prokaryotic ZIP in lipidic cubic phase with bound metal substrates (Cd 2+ at 2.7 Å and Zn 2+ at 2.4 Å).
2 de oct. de 2018 · ZIPs and ZnTs play pivotal roles in the maintenance of cellular zinc homeostasis. Interestingly, both form dimers and share a traditional transport mechanism, including two major conformational states, that is, inward-open and outward-open.
8 de abr. de 2014 · ZIP and ZnT transporters play pivotal roles in the dynamic regulation of cytosolic zinc concentration and distribution, contributing to the fine-tuning of cellular signaling pathways in immune cells (this type of signaling function of zinc is called “zinc signaling” [5, 19, 153–155]).
28 de jul. de 2017 · Cellular zinc homeostasis involves the opposing action of two families of metal transporters: the ZnT (SLC30) family that functions to reduce cytoplasmic zinc concentrations and the ZIP...
19 de feb. de 2021 · By interrogating zinc-related genes in a genome-wide RNAi screen of ferroptosis, we identified SLC39A7, encoding ZIP7 that controls zinc transport from endoplasmic reticulum (ER) to cytosol,...
9 de dic. de 2020 · Most of the human ZIPs play key roles in systemic and cellular zinc homeostasis and intracellular zinc signaling, whereas ZIP8 and ZIP14 transport multiple metal substrates and have been proposed to participate in the homeostasis of zinc, iron and manganese [[9-13]].
