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21 de may. de 2024 · Title: Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis. P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin.
21 de may. de 2024 · Introduction: The accumulation of senescent cells accelerates aging, a process further exacerbated by obesity. The decline of muscle function is a hallmark of this progression due to muscle atrophy stemming from dysregulated autophagy and mitochondrial function in skeletal muscles. p21 is one of the major regulators, which accumulates in tissues with aging and obesity. Previous studies have ...
27 de may. de 2024 · P21-activated kinases (PAK), containing six members (PAK1 to 6), function downstream of KRAS. PAK1 and PAK4 play important roles in carcinogenesis, but their combinational effect remains unknown. In this study, we have determined the effect of dual inhibition of PAK1 and PAK4 in PDA progression using knockout (KO) cancer cell lines.
27 de may. de 2024 · Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal types of cancer, and KRAS oncogene occurs in over 90% of cases. P21-activated kinases (PAK), containing six members (PAK1 to 6), function downstream of KRAS.
Hace 4 días · Programa de formación diseñado para presentar sistemáticamente el contenido enunciado en los 5 pilares del cuerpo de conocimiento (BoK) de SMRP de su última edición (2020) y fortalecer tanto de conocimiento, como de habilidades asociativas que los profesionales del mantenimiento y la confiabilidad deben poseer para enfrentar con mayor ...
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16 de may. de 2024 · Targeted genetic clearance of p21+ cells suppressed senescence-associated signatures within the fracture callus and accelerated fracture healing. By contrast, p21+ cell clearance did not alter bone loss due to aging; conversely, p16+ cell clearance, known to alleviate skeletal aging, did not affect fracture healing.
