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23 de may. de 2024 · In total, 27 patients (45%) had pathogenic complement variants and 19 (32%) had a kidney transplantation prior to ravulizumab initiation. Among extrarenal manifestations (experienced at any time during observation), the most common were gastrointestinal (n = 29 [48%]), central nervous system (n = 19 [32%]) and cardiovascular (n = 15 ...
23 de may. de 2024 · Method. We present 9 patients with an average age of 42 ± 13 years and weight of 81 ± 12.4 kg. The switch to ravulizumab was initiated 2 weeks after the last dose of eculizumab in switch patients, while in naïve patients it was initiated after excluding other causes of aHUS.
23 de may. de 2024 · Individuals with monoallelic LoF variants of IFT140 are likely to develop kidney cysts and/or atypical forms of ADPKD. However, a large proportion may remain asymptomatic or undiagnosed. There is no evidence to recommend cascade screening using genetic testing in young at risk relatives.
Hace 6 días · aHUS (atypical hemolytic uremic syndrome) is a very rare disease that causes tiny blood clots to form in the small blood vessels of your body. These blood clots can block blood flow to important organs, such as your kidneys. This can damage your kidneys and lead to kidney failure.
8 de may. de 2024 · Innovation models. Today, the U.S. Department of Health and Human Services (HHS), through the Centers for Medicare & Medicaid Services (CMS), is announcing the Increasing Organ Transplant Access (IOTA) Model.
9 de may. de 2024 · Introduction. Immunosuppressive drugs (ISD) present a narrow therapeutic window and extremely high inter- and intra-individual pharmacokinetic variability, which complicates their use in solid organ transplant recipients.
29 de may. de 2024 · Background. Antibody-mediated rejection is one of the most significant risk factors for allograft dysfunction and failure in children and adolescents with kidney transplants, yet optimal treatment remains unidentified.
