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Hace 4 días · The p21 gene contains several p53 response elements that mediate direct binding of the p53 protein, resulting in transcriptional activation of the gene encoding the p21 protein. The p53 and RB1 pathways are linked via p14ARF, raising the possibility that the pathways may regulate each other.
24 de jun. de 2024 · This study not only reveals a p53-independent apoptosis pathway in response to DNA damage, but also establishes connections between translation regulation and the DNA damage response.
2 de jul. de 2024 · It appears there is a clear consensus favoring the importance of loss-of-function over gain-of-function following mutations in p53. When p53 is inactivated, cancer cells gain a significant advantage through the loss of the tumor-suppressive properties inherent in wild-type p53.
7 de jul. de 2024 · More specifically, NUP155, in cooperation with the deacetylase enzyme HDAC4 [ 91 ], mediates translational repression of p21, one of the most important effectors of the p53 response, by manipulating the activity of FTSJ1, which is a master gene in the methylation of tRNA in human [ 90, 92, 93 ].
Hace 6 días · Dentro de nuestro genoma hay una clase de genes llamados genes supresores de tumores. Estos genes producen proteínas que actúan como frenos dentro de la célula, y cuando están encendidos en realidad impiden que la célula se divida.
Hace 2 días · p53 is the guardian of the genome and an important upstream regulator of apoptosis and other key biological functions . The essential growth-arrest and proapoptotic genes induced by activated p53 include CDKN1A (p21), PUMA, NOXA, BAK, apoptotic protease-activating factor-1 (APAF-1), TRAIL, and DR5 (62 – 66) .
Hace 6 días · Amplified products of p53 exon 4 and p21 were purified and sent for commercial Sanger sequencing (MoleQule-ON, Auckland, Newzeland). Data analysis The resulting data were statistically analyzed with Chi square χ 2 tests in order to investigate association between demographics and lesions studied, using, GraphPad Prism version 8.0 and odds ratio by an online free available software MedCalc.
