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Hace 6 días · Here, we investigated the genetic architecture of obesity by clustering the Japanese and British populations with obesity using obesity-related factors. In Step-1, we conducted a genome-wide association study (GWAS) with body mass index (BMI) as the outcome for eligible participants.
23 de jul. de 2024 · Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. Keywords: autism spectrum disorders; genetics; immune system; molecular and cellular biology.
18 de jul. de 2024 · The primary aim of meta-analysis is to aggregate association summary statistics across GWAS to estimate a combined SNP effect size and/or p value for association. This integration not only bolsters the power to detect genetic effects but also helps in exploring heterogeneity between GWAS—a critical aspect of MAGMA, as described in ...
24 de jul. de 2024 · A new study combining experimental treatments of human blood cells from thousands of individuals with flow-cytometry-based phenotyping and then genome-wide association analyses identifies genetic...
5 de ago. de 2024 · In this study, we present the random effect cistrome-wide association study (RECWAS) algorithm, innovatively designed to address the limitations of current CWAS approaches, particularly their linear assumptions regarding the contribution of SNPs to cistrome state.
5 de ago. de 2024 · Genome-wide association studies (GWASs) are unbiased genome screens of unrelated individuals and appropriately matched controls or parent-affected child trios to establish whether any...
Hace 3 días · A genome-wide association study (abbreviated GWAS) is a research approach used to identify genomic variants that are statistically associated with a risk for a disease or a particular trait. The method involves surveying the genomes of many people, looking for genomic variants that occur more frequently in those with a specific ...
