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13 de may. de 2024 · The cell wall of Mycobacterium tuberculosis (Mtb) is exceptionally complex and is essential to its success as a pathogen. Phthiocerol dimycocerosates (PDIMs) are long-chain non-polar...
1 de may. de 2024 · Their cell walls contain mycolic acid-rich, long-chain glycolipids and phosphoglycolipids (mycocides) that protect mycobacteria from cell lysosomal attack . The...
1 de may. de 2024 · Under a high magnification of 15549x, this scanning electron micrograph depicts some of the ultrastructural details seen in the cell wall configuration of a number of Gram-positive Mycobacterium tuberculosis bacteria. As an obligate aerobic organism, M. tuberculosis can only survive in an environment containing oxygen.
Hace 1 día · Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part ...
3 de may. de 2024 · Tuberculosis (TB) remains a persistent epidemic, and the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) presents a global healthcare threat. ... (3-D) cell culture model that reflects human disease gene expression patterns and causes Mtb to become pyrazinamide sensitive in vitro. Here, we identify key differences in ...
9 de may. de 2024 · In the case of M.tb dissemination, ESAT6 can be utilized to induce cytolysis of alveolar epithelial cells, thereby enabling direct dissemination from the alveolar wall . Interestingly, our findings showed that Rv2569c significantly enhanced bacterial transmigration without inducing A549 cell death in the transwell assay.
3 de may. de 2024 · Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection | PLOS Pathogens. Open Access. Peer-reviewed. Research Article. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. x. Published: May 3, 2024. https://doi.org/10.1371/journal.ppat.1012205.
