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23 de may. de 2024 · Mycobacterium tuberculosis (Mtb), ... One problem is the unique structure of the mycobacterial cell wall, which is composed of complex lipid layers, including mycolic acids, ...
- Propionate prevents loss of the PDIM virulence lipid in Mycobacterium ...
The cell wall of Mycobacterium tuberculosis (Mtb) is...
- Propionate prevents loss of the PDIM virulence lipid in Mycobacterium ...
9 de may. de 2024 · In the case of M.tb dissemination, ESAT6 can be utilized to induce cytolysis of alveolar epithelial cells, thereby enabling direct dissemination from the alveolar wall . Interestingly, our findings showed that Rv2569c significantly enhanced bacterial transmigration without inducing A549 cell death in the transwell assay.
13 de may. de 2024 · In vitro functional experiments showed that the components identified from Mtb-HAg, including HspX, GroEL1, and GroES, could dominantly expand γδ T cells from human peripheral blood with Vγ2Vδ2 T cells as the main cell subset and could stimulate the production of TNF-α and IFN-γ, while the proportion of TNF-α- and IFN-γ ...
3 de may. de 2024 · Tuberculosis (TB) remains a persistent epidemic, and the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) presents a global healthcare threat. ... (3-D) cell culture model that reflects human disease gene expression patterns and causes Mtb to become pyrazinamide sensitive in vitro. Here, we identify key differences in ...
3 de may. de 2024 · Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection | PLOS Pathogens. Open Access. Peer-reviewed. Research Article. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. x. Published: May 3, 2024. https://doi.org/10.1371/journal.ppat.1012205.
Hace 3 días · The increasing challenge of drug-resistant tuberculosis (TB) calls for the development of innovative therapeutic strategies, highlighting the potential of adjunctive immunotherapies that are both cost-effective and safe. Host-directed therapy (HDT) using immunomodulators shows promise in enhancing treatment efficacy by modulating immune responses, thereby shortening the duration of therapy and ...
