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4 de jun. de 2024 · Common anti-acetylcholinesterase drugs such as Galantamine, Rivastigmine, Donepezil, and Tacrine have significant inhibition potential. Due to side effects and safety concerns, we aimed to investigate a wide range of phytochemicals and structural analogues of these compounds.
24 de jun. de 2024 · The study examined complexes of 3LII (Acetylcholinesterase receptor) in the A and B chain with Solanine and Rivastigmine derivatives, using an in-silico approach. PyRx default sorter was used to improve docking accuracy.
21 de jun. de 2024 · Physostigmine is the only reversible acetylcholinesterase inhibitor capable of directly antagonizing the CNS manifestations of anticholinergic toxicity; it is an uncharged tertiary amine that...
5 de jun. de 2024 · Given that insects used in this study were reared on native black nightshade and crown vetch plants that produce toxic α-solanine, α-chaconine, and NPA metabolites, detoxifying symbiosis was investigated. α-Solanine and α-chaconine are two structurally related glycoalkaloids that inhibit cholinesterase activity and disrupt ...
20 de jun. de 2024 · Acetylcholinesterase (AChE), encoded by the ace gene, is a key enzyme of cholinergic neurotransmission. Insensitive acetylcholinesterase (AChE) has been shown to be responsible for resistance to OPs and CBs in a number of arthropod species, including the most important pest of olives trees, the oliv …
16 de jun. de 2024 · aims to investigate the antioxidant activity, anti-acetylcholinesterase, anti-α-glucosidase, and anti-β-lactamase activities of essential oil from S. alata. 2.
7 de jun. de 2024 · Triazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ …
