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5 de jul. de 2024 · Two types of glucose transporters are coupled with ion transport: the glucose/Na + co-transporter (SGLT) and the glucose/H + co-transporter. In the mammalian intestine, two membrane proteins, SGLT and the Na + /K + -ATPase, function together to transport glucose along an energy-dependent Na + gradient.
Hace 5 días · In the tubule’s S3 segments, glucose is coupled to Na uptake via SGLT1 at a ratio of 2 Na:1 glucose . SGLT1 also functions as a low-conductance water channel that stoichiometrically couples Na, sugar and water, with 1 glucose: 2 Na: 400 H 2 O [28,29] (Figure 1B).
Hace 6 días · Glycolysis is the metabolic pathway that converts glucose ( C6H12O6) into pyruvate and, in most organisms, occurs in the liquid part of cells (the cytosol ). The free energy released in this process is used to form the high-energy molecules adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide (NADH). [1] .
17 de jul. de 2024 · Cell - Secondary Active Transport: In some cases the problem of forcing a substrate up its concentration gradient is solved by coupling that upward movement to the downward flow of another substrate. In this way the energy-expending diffusion of the driving substrate powers the energy-absorbing movement of the driven substrate from low ...
4 de jul. de 2024 · Sodium-glucose cotransporter 2 (SGLT2) inhibitors facilitating glucose excretion and lowering the blood glucose levels, initially developed for T2DM treatment. Beyond glycemic control,...
10 de jul. de 2024 · The most common form of diabetes is diabetes mellitus, a metabolic disorder in which there is an inability to maintain carbohydrate and lipid homeostasis due to disturbances in insulin function, resulting in hyperglycemia and excess urinary excretion of glucose as well as hyperlipidemia.
Hace 5 días · Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell.
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