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9 de may. de 2024 · p53 was discovered 45 years ago as an SV40 large T antigen binding protein, coded by the most frequently mutated TP53 gene in human cancers. As a transcription factor, p53 is tightly regulated by a rich network of post-translational modifications to execute its diverse functions in tumor suppression.
9 de may. de 2024 · The past 45 years of p53 research represent a remarkable journey. As discussed previously, countless discoveries result in a much better understanding of the complexity of p53 functions under different physiological settings.
Hace 1 día · The p53 protein is the master regulator of cellular integrity, primarily due to its tumor-suppressing functions. Approximately half of all human cancers carry mutations in the TP53 gene, which not only abrogate the tumor-suppressive functions but also confer p53 mutant proteins with oncogenic potential. The latter is achieved through so-called gain-of-function (GOF) mutations that promote ...
10 de may. de 2024 · Abstract. Clear-cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival. Functional inactivation of the wild-type p53 protein is implicated in ccRCC therapy resistance, but the detailed mechanisms of p53 malfunction are still poorly characterized.
16 de may. de 2024 · 16 May 2024. Vol 384, Issue 6697. pp. 785 - 792. DOI: 10.1126/science.adh7950. Contents. Editor’s summary. Abstract. DNA damage inhibits translation. DNA damage causes ribosome stalling. Translation inhibition and ribosome stalling require SLFN11. SLFN11 mediates p53-independent apoptosis.
Hace 1 día · Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas (STSs) in elderly patients, with a slight predominance in males. It primarily affects the extremities and girdles, especially in the lower limbs [1]. A characteristic clinical feature of MFS is its propensity for local recurrence (LR), whose incidence ranges from 20% to 60% [2-4] after 5 years, more frequent than other STS ...
13 de may. de 2024 · MDM2 influences tumor development and progression in breast cancer through multiple pathways. Firstly, P21 is a downstream cell cycle protein kinase inhibitor of P53, and in breast cancer, it can block cell cycle progression, exerting an anti-cancer effect.
