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12 de oct. de 2011 · The cell cycle has four sequential phases. Arguably the most important phases are S phase, when DNA replication occurs, and M phase, when the cell divides into two daughter cells. Separating S and M phase are two gap phases referred to as G 1 and G 2. G 1 follows on from mitosis and is a time when the cell is sensitive to positive and negative ...
1 de feb. de 2008 · Abstract. The androgen receptor (AR) is a critical effector of prostate cancer development and progression. The dependence of this tumor type on AR activity is exploited in treatment of disseminated prostate cancers, wherein ablation of AR function (achieved either through ligand depletion and/or the use of AR antagonists) is the first line of ...
1 de abr. de 1997 · The cell cycle and cancer Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2776-8. doi: 10.1073/pnas.94.7.2776. Authors K Collins 1 , T Jacks, N P Pavletich. Affiliation 1 Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. PMID: 9096291 PMCID: ...
2 de jun. de 2020 · In this Perspective, in accordance with Hadfield’s original definition, we use the term dormant cancer cells to refer to non-proliferating cancer cells that have undergone G0–G1 cell cycle arrest.
13 de mar. de 2020 · Dysregulation of the cell cycle and genetic alterations in cell-cycle regulatory proteins lead to uncontrolled cell proliferation in many solid cancer types, including BC [13,14], which is a frontier in biomedical research for designing synthetic inhibitors of CDKs as anticancer drugs .
Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past two decades, cancer genetics has shown that hyperactivating mutations in growth signalling networks, coupled to loss of function of tumour suppressor proteins ...
In addition, the damaged version of p53 found in cancer cells cannot trigger cell death. Figure 6.3.1 6.3. 1: (a) The role of p53 is to monitor DNA. If damage is detected, p53 triggers repair mechanisms. If repairs are unsuccessful, p53 signals apoptosis. (b) A cell with an abnormal p53 protein cannot repair damaged DNA and cannot signal apoptosis.
