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11 de may. de 2023 · Article on Use of Developmental Midazolam and 1-Hydroxymidazolam Data with Pediatric Physiologically Based Modeling to Assess Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyl Transferase 2B4 Ontogeny In Vivo., published in Drug metabolism and disposition: the biological fate of chemicals 51 on 2023-05-11 by Trevor N Johnson+4.
1 de feb. de 2018 · Abstract. This chapter describes the theoretical and mechanistic basis, and public health implications, of the Developmental Origins of Health and Disease (DOHaD) paradigm, which has emerged from overwhelming epidemiological, clinical, and experimental evidence demonstrating the importance of early life development in influencing an individual’s susceptibility to later life disease risk.
13 de feb. de 2023 · Chronological age is the number of years you've been alive, while biological age refers to how old your cells and tissues are based on physiological evidence. If you're especially healthy and fit for your age, your biological age may well be lower than your chronological age. But if you're sedentary, chronically ill, or in poor physical ...
Humans spend about one-third of their lives asleep, yet most individuals know little about sleep. Although its function remains to be fully elucidated, sleep is a universal need of all higher life forms including humans, absence of which has serious physiological consequences. This chapter provides an overview of basic sleep physiology and describes the characteristics of REM and NREM sleep ...
Farming has become increasingly visible in recent years, following a growing public interest in how food is produced. Anthropologists have been studying farming since the founding of the discipline. This entry summarises the origins of farming and agricultural intensification before analysing three themes of the social anthropology of farming. First, farming is dependent on relations of power ...
Monoclonal antibodies (mAbs) can be engineered to have "extended half-life" and "catch and release" properties to improve target coverage. We have developed a mAb physiologically-based pharmacokinetic model that describes intracellular trafficking, neonatal Fc receptor (FcRn) recycling, and nonspeci …
1 de ene. de 2018 · Physiologically based pharmacokinetic (PBPK) models describing pregnancy, in utero development, lactation, and neonatal growth in laboratory animals and humans are commonplace in the scientific literature today. Early-life stages and maternal reproductive states are generally perceived as potentially sensitive to the disrupting effects of drugs ...
