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Corpus ID: 78311981; Early care and treatment with a neuroprotective drug, gacyclidine, in patients with acute spinal cord injury @inproceedings{Tadi2003EarlyCA, title={Early care and treatment with a neuroprotective drug, gacyclidine, in patients with acute spinal cord injury}, author={Marc Tadi{\'e} and Manuel Gaviria and J. F. Math{\'e} and P Menthonnex and Georges Loubert and Jacques ...
Developmental Mechanisms of Regeneration. David L. Stocum, in Principles of Regenerative Medicine, 2008 Soluble Factors. A number of soluble agents have been found to protect neurons of the damaged mammalian spinal cord and to neutralize or remove molecules inhibitory to regeneration (Ramer et al., 2005).Neuroprotectives include molecules such as methylprednisolone and gacyclidine.
1 de feb. de 2001 · Gacyclidine (GK11), a phencyclidine, is a non-competitive NMDA receptor antagonist, with a selective affinity for NR2B receptors, that had been shown to prevent glutamate-induced neuronal death in ...
7 de jun. de 2006 · Gacyclidine is a new phencyclidine derivative with neuroprotective properties. Tritiated gacyclidine and its enantiomers bind to NMDA receptors with binding parameters similar to those of other non-competitive NMDA receptor antagonists.
25 de ago. de 2000 · The aim of this study was to analyze the optimal time-window for neuroprotection by a novel NMDA antagonist, Gacyclidine, after experimental spinal cord injury, in terms of its functional, histopathological and electrophysiological effects. This molecule has already demonstrated its capacity for red …
7 de jun. de 2006 · Gacyclidine is a new phencyclidine derivative with neuroprotective properties. Tritiated gacyclidine and its enantiomers bind to NMDA receptors with binding parameters similar to those of other non-competitive NMDA receptor antagonists.
Gacyclidine, a novel, noncompetitive NMDA receptor antagonist, was injected (i.v.) into rats at three different doses to determine if the drug could promote behavioral recovery and reduce the behavioral and anatomical impairments that occur after bilateral contusions of the medial frontal cortex (MFC). In the Morris water maze,contused rats treated with gacyciidine at a dosage of 0.1 mg/kg ...
