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31 de mar. de 2022 · p53-p21-RB target genes mostly do not bind p53 in their promoters. In order to evaluate a potential direct regulation by p53, the targets were also checked for p53 binding in their promoter region.
p21 / waf1は、ヒト6番染色体 (6p21.2) に位置するcdkn1a遺伝子にコードされるタンパク質である 。 サイクリン依存性キナーゼ阻害因子1 （cyclin-dependent kinase inhibitor 1）あるいは CDK相互作用タンパク質1 (CDK-interacting protein 1) としても知られている。
The cell cycle inhibitor p21(CDKN1A) is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent ki …
14 de ago. de 2019 · p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity. Although tumor-suppressor function of p21 is the most studied aspect of this protein in cancer, the role of p21 in ...
p21 places stressed cells under immunosurveillance. p21 induced by cells under duress activates an Rb-dependent transcriptional program that produces CXCL14 and other secreted factors. CXCL14 promptly recruits macrophages, which disengage if stressed cells recuperate and normalize p21 within 4 days.
The cyclin-dependent kinase inhibitor p21 is usually considered to be a key promoter of the latter. Hsu and colleagues elegantly demonstrated in vitro that initial expression of p21 after chemotherapy exposure controls downstream cell fate after DNA damage induced by 1-day treatment with doxorubicin. They used a CRISPR-based p21 fluorescence ...
21 de ago. de 2019 · Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein. p21 is transcriptionally controlled by p53 and p53-independent pathways. Its expression is increased in response to various intra- and extracellular stimuli to arrest the cell cycle ensuring genomic stability ...
