Resultado de búsqueda
1 de mar. de 2021 · This first part provided the life tables, whose data were used to estimate the parameters of the Logan, Briére, and Sharpe and De Michele development rate functions. The second part of the work concerns the application of a physiologically based model described by a first order partial differential equation.
14 de oct. de 2023 · Article on Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) modeling approach., published in Cancer chemotherapy and pharmacology 93 on 2023-10-14 by Liangang Chen+4. Read the article Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone ...
3 de may. de 2024 · The mechanistic model, i.e., the physiologically-based digital twin was trained and validated on various published experimental data 24,28,29,33,37,50,51,52,53,54.An overview of the framework of ...
physiology: [noun] a branch of biology that deals with the functions and activities of life or of living matter (such as organs, tissues, or cells) and of the physical and chemical phenomena involved — compare anatomy.
Hisham El-Masri, Nicole Kleinstreuer, Ronald N. Hines, Linda Adams, Tamara Tal, Kristin Isaacs, Barbara A. Wetmore, Yu-Mei Tan, Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards, Toxicological Sciences, Volume 152, Issue 1 ...
13 de ago. de 2018 · Extracorporeal life support (ECLS), such as dialysis or extracorporeal membrane oxygenation (ECMO), provides an artificial organ that is life‐saving for patients with organ failure. However, in treating patients on ECLS, one of the challenges is understanding and appropriately compensating for the effect of the extracorporeal circuit on drug pharmacokinetics (PKs).
This paper focuses on the retrospective evaluation of physiologically based pharmacokinetic (PBPK) techniques used to mechanistically predict clearance throughout pediatric life. An intravenous tramadol retrograde PBPK model was set up in Simcyp® using adult clearance values, qualified for CYP2D6, CYP3A4, CYP2B6, and renal contributions.
