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Around 12 million m3 of medical devices are sterilized by radiation annually. More than 40 per cent of all single-use medical devices produced worldwide are sterilized with gamma irradiation. The IAEA helps its Member States set up radiation facilities and provides guidelines for the use of sterilization applications that use radiation.
18 de ene. de 2018 · During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors.
18 de mar. de 2021 · Medical equipment, devices, and drugs are most commonly sterilized using gamma (γ)-irradiation. The main advantage of γ-irradiation is its high level of penetration and isothermal characteristics, which can appropriately manage heat-sensitive materials include inorganic metal oxides, polymer blends, or liquid crystals.
Sterility by gamma irradiation is achieved mainly by the alteration of nucleic acid and preventing the cellular division. This review focuses on the extensive application of gamma sterilization to a wide range of pharmaceutical components including active pharmaceutical ingredients, excipients, final drug products, and combination drug ...
2.1 Gamma Rays. Gamma radiation, a form of ionizing radiation, became an established method for sterilizing single-use pharmaceutical, food, and cosmetic products. It is characterized by its ease of use and compatibility with diverse packaging materials.
27 de feb. de 2018 · Gamma-ray irradiation at doses of ≥15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. γ-PPy substrates also showed...
18 de ene. de 2018 · During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors.
