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16 de abr. de 2020 · GLUTs are divided into two structurally and functionally distinct types: (i) GLUTs, which operate by facilitated diffusion 1 , 2 ; and (ii) sodium–glucose cotransporters (SGLTs), which actively transport glucose against the concentration gradient by coupling with sodium 3 , 4 .
INTRODUCTION. Sodium-glucose cotransporter (SGLT) activity mediates apical sodium and glucose transport across cell membranes. Cotransport is driven by active sodium extrusion by the basolateral sodium/potassium-ATPase, thus facilitating glucose uptake against an intracellular up-hill gradient.
The low-affinity SGLT transporter had an apparent coupling stoichiometry of 1 Na:1 sugar, whereas for the high-affinity transporter, it was 2 Na:1 sugar. The low-affinity transporter became to be known as SGLT2, and the high-affinity transporter was determined to be SGLT1 .
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST).
8 de dic. de 2021 · SGLT1, the first member of the large sodium–solute symporter (SSS) family 2 to be identified, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling ...
7 de ago. de 2020 · The concept that transport of glucose across the intestinal brush border membrane (BBM) requires an active mechanism that is achieved through coupling of transport to the inwardly directed Na + gradient has already been disclosed in 1960 [ 26 ].
Na + /glucose cotransporters (SGLTs) are responsible for the “secondary-active” transport of glucose and other substrates across cellular membranes. They concentrate glucose inside the cell using electrochemical energy from the transmembrane Na + gradient, employing an alternating access cotransport mechanism.
