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Higher baseline risk is a major factor for the absolute risk of fractures, but in most studies the relative reduction in the risk of fractures was found to be mostly independent of baseline risk factors.
19 de ago. de 2020 · The absolute risk of atypical femur fracture remained very low as compared with reductions in the risk of hip and other fractures with bisphosphonate treatment.
3 de mar. de 2016 · Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders (for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associat...
Abstract. Postmenopausal osteoporosis is a chronic condition due to decreased bone mass, leading to reduced bone strength and increased fracture risk. Currently available pharmacological treatments include antiresorptive agents (bisphosphonates and raloxifene) and bone-forming agents (strontium ranelate and two different parathyroid peptides).
Among women with normal and low bone mass, FRAX (including BMD) was an overall better predictor of hip fracture risk (AUC = 0.78 and 0.70, respectively) than major osteoporotic fractures (AUC = 0.64 and 0.62).
The investigators determined that many factors, in addition to low bone mineral density, contribute independently to the risk of fracture, including age, history of maternal hip fracture, low body weight, height, poor health, previous hyperthyroidism, poor depth perception, tachycardia, previous fracture, and benzodiazepine use.
Included risk factors comprise femoral neck bone mineral density, prior fractures, parental hip fracture history, age, gender, body mass index, ethnicity, smoking, alcohol use, glucocorticoid use, rheumatoid arthritis, and secondary osteoporosis.
