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1 de feb. de 2023 · The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication–transcription complex (RTC) 1. Accordingly, the RTC is a target for...
- Structures and functions of coronavirus replication–transcription ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
- Structure of replicating SARS-CoV-2 polymerase | Nature
Here we present a cryo-electron microscopy structure of the...
- Structures and functions of coronavirus replication–transcription ...
Here we present a cryo-electron microscopy structure of the SARS-CoV-2 RdRp in an active form that mimics the replicating enzyme. The structure comprises the viral proteins non-structural protein 12 (nsp12), nsp8 and nsp7, and more than two turns of RNA template-product duplex.
1 de feb. de 2023 · The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication–transcription complex (RTC) 1. Accordingly, the RTC is a target for clinically approved antiviral nucleoside analogues, including remdesivir 2.
22 de jun. de 2022 · Nonstructural proteins (also known as replicase proteins) with versatile biological functions play central roles in viral replication and transcription inside the host cells, and they are the most conserved target proteins among the SARS-CoV-2 variants.
The main protease (M pro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a key enzyme, which extensively digests CoV replicase polyproteins essential for viral replication and transcription, making it an attractive target for antiviral drug development.
