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5 de mar. de 2013 · Epub 2012 Nov 26. Authors. David G Bailey 1 , George Dresser , J Malcolm O Arnold. Affiliation. 1 Lawson Health Research Institute, London, Ont. david.bailey@lhsc.on.ca. PMID: 23184849. PMCID: PMC3589309. DOI: 10.1503/cmaj.120951. No abstract available. Publication types. Review. MeSH terms. Acute Kidney Injury / chemically induced.
23 de sept. de 2022 · Dr. David Bailey, shown holding a grapefruit in 2017, was a Canadian Olympic runner and a pharmacologist who made the game-changing discovery that consuming grapefruit juice has an effect...
3 de mar. de 2013 · Drugs that interact with grapefruit have all of the following characteristics: they are administered orally, they have very low to intermediate absolute bioavailability, and they are metabolized by the cytochrome P450 3A4 enzyme (CYP3A4).
29 de sept. de 2022 · David Bailey was a Canadian pharmacist and researcher who accidentally found that grapefruit juice can inhibit the enzyme CYP3A4, affecting the absorption of many drugs. Learn how his discovery improved the safety of consumers worldwide and what drugs are affected by grapefruit.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey. Their first published clinical report on grapefruit drug interactions was in 1991.
This review identifies the key scientific concepts and clinical implications of grapefruit-drug interactions relevant to medical practice. We focus on grapefruit because it is the most widely examined, but other citrus fruits may have similar consequences.
2 de abr. de 2013 · After 20 years and hundreds of research publications on the topic of grapefruit–drug interaction, is there not enough well-documented science to predict with high likelihood the adverse effects and toxicity before unnecessary exposure?
