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Atenolol is an ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent, a sympatholytic agent, a xenobiotic and an environmental contaminant.
Atenolol is a synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients.
Atenolol has a pKa of 9.6; it undergoes ionization in the stomach and intestine thus its oral bioavailability is low due to inefficient absorption through membranes. The bioavailability of atenolol is between 45% and 55% of the given dose and is not increased by administration of the drug in a solution form [156-158].
Fosforilación coordinada por la PKA de varias dianas, como el canal de calcio de tipo L (CCTL) de la membrana plasmática o el canal de calcio RyR2 del retículo sarcoplásmico; el resultado es un aumento de la concentración citosólica de Ca 2+ disponible para la contracción del músculo cardiaco.
24 de abr. de 2021 · In cardiac myocytes, the main driver of cardiac contractility is the activation of the β-adrenoceptor-signaling cascade leading to increased cellular cAMP production and activation of its main effector, the cAMP-dependent protein kinase (PKA).
Entre los compuestos analizados se incluyeron el uracilo y una serie de betabloqueantes preparados en agua y acetonitrilo (50:50) con una concentración de 1 mg/ml, que se mezclaron posteriormente a partes iguales para obtener una disolución de aproximadamente 0,143 μg/ml de atenolol, pindolol, acebutolol, metoprolol, oxprenolol, alprenolol y pro...
Atenolol is a second-generation β-1–selective adrenergic antagonist that helps lower the heart rate and blood pressure of patients while also decreasing myocardial contractility. Off-label uses of atenolol include the treatment of arrhythmias, migraine prophylaxis, paroxysmal supraventricular tachycardia, alcohol withdrawal, thyrotoxicosis ...
