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10 de sept. de 2021 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with...
14 de ago. de 2023 · Genetics, Cancer Cell Cycle Phases. Anthony A. Mercadante; Anup Kasi. Author Information and Affiliations. Last Update: August 14, 2023. Go to: Introduction. Most cells in the body go through a cycle of life in which their genetic information is retained, fixed, and passed down to daughter cells through a highly coordinated and regulated process.
17 de jun. de 2003 · The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer - PMC. Journal List. Cell Prolif. v.36 (3); 2003 Jun. PMC6496723. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.
Abstract. Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cycle checkpoints operate as DNA surveillance mechanisms that prevent the ...
12 de oct. de 2011 · PDF. Tools. Share. Abstract. Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability.
3 de ene. de 2022 · Cell cycle machinery and its function in cancer. After the identification of first cell cycle regulator gene cdc28 (the analog of CDK1 in yeast) in early 1970s [ 1 ], the long history of cell cycle study reveals the mechanisms of how cell cycle functions as the fundamental event in cell biology [ 2, 3 ].
Cell cycle deregulation is a common feature of human cancer. Cancer cells frequently display unscheduled proliferation, genomic instability (increased DNA mutations and chromosomal...
