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1 de oct. de 2022 · Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of carriers in DPI formulations.
Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence of the carrier is aimed at overcoming issues of poor flowability and dispersibility, associated with the cohesive nature ….
1 de dic. de 2021 · Sugars, particularly lactose, are used as NBEs in many marketed inhalation dry powders. Their main function is to act as a diluent and powder flow enhancer, which together enable the accurate dosing of small amounts of micronized API particles (Figure 3 a).
5 de dic. de 2016 · Whilst many DPI products have, and continue to be developed using a single formulation excipient, the commercialisation of DPI products which contain the two excipients lactose monohydrate and magnesium stearate, namely the ‘dual excipient platform’ has recently been achieved.
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of carriers in DPI formulations.
1 de may. de 2019 · While the use of inhalable micronized lactose as a carrier, and the use of leucine and MgSt as dispersibility enhancers in DPI formulations, has been established, no FTIR studies have investigated the possible interactions between glucagon and these excipients.
15 de ago. de 2012 · Lactose, 4-(b-D-galactosido-)-D-glucose, can be obtained in either two basic isomeric forms, α and β-lactose, or as an amorphous form. 31 Historically, lactose monohydrate was an obvious choice for use as a carrier excipient.
