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Hace 1 hora · To measure the effect of FR900359 on receptor internalization, ΔQ-GRK and CRISPR/Cas9 HEK293 Control cells were seeded as described above and transfected with 0.1 µg M5R-NLuc and 1 µg early ...
Hace 1 hora · These genes can be ablated by CRISPR/Cas9 gene editing using an all-in-one plasmid vector pTM1285 described in detail here . This is a relatively uncomplicated process using the following steps: 1. Use CRISPOR or other similar tools to identify suitable guides for a candidate gene. 2.
Hace 3 horas · Overview. PackGene’s proprietary π-Alpha 293 AAV High-yield Platform uses uniquely designed RC plasmid in the triple-plasmid transfection system to increase AAV production by 3 to 8 times for various AAV serotypes. This technology is paired with both in-process upstream and downstream QbD optimizations to increase total AAV yield up to 10 fold.
Hace 2 horas · The team at CSIR-IGIB, led by Dr Debojyoti Chakraborty, worked on improving a Cas9 protein used in the CRISPR gene editing system. The commonly used Cas9 protein was enhanced from a bacterium ...
Hace 1 día · Hyderabad: In a collaborative work, scientists from Hyderabad-based LV Prasad Eye Institute (LVPEI), CSIR- Institute of Genomics and Integrative Biology (CSIR-IGIB) and others have presented an enhanced CRISPR-Cas9 based genome editing system that is more precise and efficient than existing technologies. The genome editing system has high specificity, extended flexibility for genome coverage ...
Hace 1 hora · 此次公布的数据显示，在I期试验中，三名初始患者在剂量递增阶段接受了0.1 mg/kg剂量的NTLA-2001，在第28天，其血清TTR中位减少52%。如预期，0.1 mg/kg剂量导致的血清TTR减少低于目标水平。
Hace 1 día · 双靶点敲除lincCG1基因导致大片段缺失，产生lincCG1基因功能丧失型（LincCG1-type）突变体，lincCG1功能丧失可导致大豆7S（β–conglycinin）α′-,α-,与β-三个主要致敏亚基同时缺失，LincCG1-type突变体主要农艺及品质性状分析结果表明：T4代Cas9-free、LincCG1-type突变品系（CF-LincCG1）的产量性状相对于野生型对照 ...
