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Hace 10 horas · Introduction The activity changes of cytochrome P450 (CYP450) enzymes, along with the complicated medication scenarios in diabetes mellitus (DM) patients, result in the unanticipated pharmacokinetics (PK), pharmacodynamics (PD), and drug–drug interactions (DDIs). Physiologically based pharmacokinetic (PBPK) modeling has been a useful tool for assessing the influence of disease status on CYP ...
Hace 10 horas · On May 22, 2024, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) announced the availability of a final guideline on Drug Interaction Studies (M12) as well as an M12 Question and Answers document (M12 Q&A). The guideline provides recommendations to promote a consistent approach in ...
Hace 10 horas · In recent years, a series of recommendations have been issued regarding the administration of drugs because of awareness of the serious side effects associated with certain classes of drugs, especially in vulnerable patients. Taking into account the obligation of the continuous improvement of professionals in the medical fields and the fact that we are in the midst of a “malpractice ...
Hace 10 horas · One promising approach is the use of anti-fibrotic drugs. These drugs work by interrupting the fibrotic process at various stages. For example, certain medications are designed to inhibit the ...
Hace 10 horas · The adoption of simulation technology and digital twins marks just the beginning of a technological renaissance in drug supply chain management. Looking forward, AI’s predictive analytics will ...
Hace 10 horas · Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. They are useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. They can be given intravenously or by mouth, and the tablet forms exist in both long- and ...
Hace 10 horas · The interaction of Suk-Saiyasna remedy with GABAA and CB1 receptor-targeting drugs: Enhancing hypnotic and sedative effects in in vivo models Damjuti, Watchara; ... After a relaxation of drug control laws in Thailand, its use re-emerged. This study examines the Suk-Saiyasna remedy’s impact on rodent behavior and its receptor effects.
