Resultado de búsqueda
Hace 7 horas · We selected top-scoring 200 compounds based on their “Minimized Affinity” scores (−11.85 ~ −8.10 kJ/mol). According to the ligand–protein interactions observed from the cocrystal structure and the observation of Ogawa et al. , the hydrogen bonds with Lys188 and Leu241 play a crucial role in ligand–protein recognition.
Hace 7 horas · class MainScreen extends StatelessWidget { MainScreen({super.key}); List<Widget> pageList = const [ HomePage(), FlightsPage(), DirectoryPage(), GuidePage() ]; @overr...
Hace 7 horas · The massive blaze sent 36 fire engines and seven ladder trucks to the 2700 block of Middlefield Road on Monday morning. Exterior scaffolding and the building’s framework and interior structure ...
Hace 7 horas · It is a scaffold palace of a pop-up stadium, 30 miles outside Manhattan. ... As Twenty20 games go, it made a good advert for Test cricket because it was oddly compelling despite the slow scoring. The New Yorkers – most of them Sri Lankan expats but with a good scattering of South Africans, Indians, ...
Hace 7 horas · Abstract. Therapies that abrogate persistent androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) remain an unmet clinical need. The N-terminal domain of the AR that drives transcriptional activity in CRPC remains a challenging therapeutic target. Herein we demonstrate that BCL-2–associated athanogene-1 (BAG-1) mRNA is highly expressed and associates with signaling ...
Hace 7 horas · The PD-1/PD-L1 complex is an immune checkpoint responsible for regulating the natural immune response, but also allows tumors to escape immune surveillance. Inhibition of the PD-1/PD-L1 axis positively contributes to the efficacy of cancer treatment. The only available therapeutics targeting PD-1/PD-L1 are monoclonal antibody-based drugs, which have several limitations. Therefore, small ...
Hace 7 horas · To test the main hypothesis underlying this study, namely that the emotional experience triggered by the five categories of the video-clips is linked to the inner physiology of the stomach, we conducted a mixed model analysis (Model 1, see Data analysis session and Appendix 1 for details) with emotional VAS score as dependent variable, type of video clip and item as independent factors, and ...
