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Hace 11 horas · Activation of caspases to induce apoptosis has been the prevailing concept in many cytotoxic chemotherapy and ionizing radiation treatments for cancer [1,2,3].However, there is growing recognition ...
Hace 11 horas · Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) of PDAC has propelled the development of immunotherapeutic and targeted therapeutic strategies with a promising future. The emergence of single-cell sequencing and mass spectrometry technologies, coupled with spatial omics ...
10 de jul. de 2024 · Molecular studies have stratified bladder cancer according to the risk of recurrence and progression as well as risk of treatment response. Choi et al. demonstrated that although MIBC basal tumor is more related to sarcomatoid and squamous differentiation, metastatic disease, and aggressive disease, it responds better to neoadjuvant chemotherapy (NAC); luminal tumors are also more associated ...
Hace 11 horas · The concept of PROTAC was developed by Deshaies group in 2001 [], and soon after it gained wide popularity in the field of molecular oncology because it proved to be very useful for the functional analysis of cancer-related kinases and their substrates.Such a molecular engineering approach using bifunctional chemical probes looks like a versatile tool for targeted degradation of specific proteins.
Hace 11 horas · Most TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a comprehensive investigation for the entire family in gastric cancer (GC). By combining the TCGA and GEO databases, common TRIM family members (TRIMs) were obtained to investigate gene expression, gene mutations, and clinical prognosis. On the basis ...
Hace 11 horas · Downregulated LINC00908 in gastric cancer was associated with patients’ advanced development and poor prognosis. LINC00908 might suppress gastric cancer via sponging miR-627-3p, which is a potential therapeutic target for gastric cancer. Disclosures. Institutional review board statement: Not applicable. Assistance with the article: None.
Hace 11 horas · Lung adenocarcinoma (LUAD) is a significant planetary health challenge with its high morbidity and mortality rate, not to mention the marked interindividual variability in treatment outcomes and side effects. There is an urgent need for robust systems biomarkers that can help with early cancer diagnosis, prediction of treatment outcomes, and design of precision/personalized medicines for LUAD ...
