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  1. 10 de oct. de 2020 · We carefully titrated PEEP in our patients to avoid potential adverse effects of high PEEP levels in lungs with rather low elastance. That notwithstanding, we identified that high PEEP levels were required for optimized oxygenation, while driving pressure remained within margins commonly considered safe.

  2. 1 de sept. de 2020 · Although mechanical ventilation (MV) is a life-saving intervention, prolonged MV can lead to deleterious effects on diaphragm function, including vascular incompetence and weaning failure. During MV, positive end-expiratory pressure (PEEP) is used to maintain small airway patency and mitigate alveol …

  3. 12 de abr. de 2023 · Table 4.1 depicts the potential advantages and possible adverse effects of increasing levels of PEEP. Table 4.1 Increasing levels of PEEP: pros and cons. Full size table. 3 How Do We Titrate PEEP? 3.1 PEEP Tables. The ARDS-net trial applied PEEP using a table based on the FiO 2 requirement .

  4. Initial studies from the 1970s examined the effect of PEEP on ICP and yielded conflicting results [7, 8]. Frost demonstrated that applying PEEP between 5 and 12 cm H 2 O (and even transiently up to 40 cm H 2 O) improved arterial oxygenation without raising ICP [ 7 ], whereas Shapiro reported a >10 mmHg increase in ICP in more than 50 % of their cohort when PEEP was applied in the 4–8 cm H 2 ...

  5. 9 de abr. de 2023 · The median PEEP at baseline was 12 (10–15) cmH2O and the PEEP-test resulted in a median decrease in PEEP of 7 (5–10) cmH2O, without difference between volume responsive and unresponsive patients. Among volume responsive patients, the PEEP-test induced a significant increase in CI of 16% (12–20%) (from 2.4 ± 0.7 to 2.9 ± 0.9 L/min/m2, p < 0.0001) in comparison with volume ...

  6. The beneficial effects of the use of PEEP include: the improvement of oxygenation, recruitment of lung units, and improvement of compliance. Other effects can be adverse, like decreasing cardiac output, increased risk of barotrauma, and the interference with assessment of hemodynamic pressures.

  7. 12 de jun. de 2024 · To minimize these adverse effects, it is essential for healthcare professionals to recognize the presence of auto-PEEP, understand its causes, and implement appropriate management strategies. Management Strategies. The management of auto-PEEP involves a combination of ventilator adjustments and optimization of the patient’s clinical condition.