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21 de nov. de 2022 · Significance. In this study, we used an efficient and simple synthetic phage engineering platform to generate tailor-made and biologically contained phages for the treatment of drug-resistant and difficult-to-treat bacterial infection. The biocontained phages were genetically virion gene deficient but phenotypically functional and rescued ...
The history of Armed Biological Containment Area-14 begins in 1870, with Melvin Windhand's discovery of silver deposits on the slopes of Mount Abraxas. Windhand opened Clutch Mine soon thereafter. Less than a year later, miners unearthed SCP-7587, attracting notice from the American Secure Containment Initiative.
BSL-4 containment is required for dangerous/exotic agents that pose high risk of life-threatening disease. Projects in the BSL-4 group are prohibited. Potentially Hazardous Biological Agents Rules for use of microorganisms (including bacteria, viruses, viroids, prions, rickettsia, fungi, and parasites), recombinant DNA (rDNA) technologies or ...
Bioengineered probiotics represent the next generation of whole cell–mediated biotherapeutics. Advances in synthetic biology, genome engineering, and DNA sequencing and synthesis have enabled scientists to design and develop probiotics with increased stress tolerance and the ability to target specific pathogens and their associated toxins, as well as to mediate targeted delivery of vaccines ...
biological containment: Any measure used to prevent the replication of recombinant DNA in microorganisms in nature and confine genetically engineered organisms to the lab, by creating biological barriers that prevent their growth outside. Biocontainment strategies include using vectors and host organisms that have been modified to minimise ...
When biosafety for contained use is addressed in international fora and discussions, often the topic is limited to working with genetically modified organisms (GMOs) in facilities such as laboratories, animal facilities, and greenhouses. However, the scope of biosafety in containment encompasses many other types of biological materials, such as human, animal and plant pathogens, nucleic acids ...
17 de ene. de 2018 · We have addressed the biological containment of GMO spores by utilizing the concept of a thymineless death, a phenomenon first reported 6 decades ago. Using Bacillus subtilis, we have inserted chimeric genes in the two thymidylate synthase genes, thyA and thyB, using a two-step process. Insertion is made first at thyA and then at thyB whereby ...
