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16 de ene. de 2024 · The opioid crisis doesn’t get as many headlines as it used to before Covid-19, but the news remains stubbornly, shockingly bad. Decades into the deadliest drug overdose epidemic in American ...
26 de oct. de 2020 · The relatively low harm rankings of prescription opioids in our study stand in stark contrast to the high level of stigmatization of illicit opioids. These findings are congruent with the multi-decision analysis of nine experts (8 from the United Kingdom and 1 from the Netherlands) suggesting that the overall harms of non-medically used prescription opioids are less than half that of injected ...
It is well known that the use of prescription opioid medications, more than other medications, is associated with risks for misuse, abuse, and diversion.1–3 The government and pharmaceutical companies have addressed this issue by implementing specific strategies to minimize the risks associated with prescription drugs in general and with opioids in particular.
11 de dic. de 2019 · But benzodiazepines also presented unforeseen risks. They work by binding to receptors in the brain called GABA, bringing calm and drowsiness. But over time (about 4 weeks in 50% of patients, says David Fiellin, MD, an internal medicine and addiction medicine specialist at Yale Medicine), you may need higher doses to get the same sense of relief.
The therapeutic potential of κ-opioids for treatment of pain and addiction. The therapeutic potential of κ-opioids for treatment of pain and addiction. Neuropsychopharmacology. 2011 Jan;36 (1):369-70. doi: 10.1038/npp.2010.137.
Although the long-term use of opioids to treat chronic pain suggests that pain may interfere with the development of tolerance to opioids in humans (Cowan et al., 2001; Portenoy et al., 2007), data derived from both animals and drug abusers demonstrate that tolerance is a real potential problem with opioid use.
6 de may. de 2016 · Although the addiction potential became widely known decades ... Opioids and BZDs are the two most common classes of prescription drugs involved in overdose deaths.29 Death rates for all prescription drugs have soared in recent years.30 Individuals who filled prescriptions for a BZD in addition to an opioid had a nearly 15-fold ...
