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Introduction. High grade prostatic intraepithelial neoplasia (HG-PIN) and atypical small acinar proliferation (ASAP) are widely considered precancerous lesions in the prostate. Pathologically, prostatic intraepithelial neoplasia involves a continuum of intra-luminal proliferation of atypical secretory cells lining pre-existing ducts and acini in the prostate [].
19 de nov. de 2008 · Atypical small acinar proliferation is again another pathologic finding. It is something that's seen in the prostate that may actually increase a man's risk of ultimately developing prostate cancer.
1 de ene. de 2015 · In atypical lobular hyperplasia, the acini of a lobular unit are expanded and filled with small, monotonous, round or polygonal cells with a lack of cohesion and a loss of acinar lumens .
10 de mar. de 2009 · March 10, 2009. By Harvard Prostate Knowledge. At least initially, the pathology report is one of the most important factors in the management of your prostate health, especially if you have been diagnosed with cancer. For example, it can provide valuable information about the location and extent of the cancer, thus helping your physician ...
17 de oct. de 2012 · Atypical small-cell acinar proliferation ... Deeper levels unveil a total of 12 acini showing the same nuclear atypical features (c – HE, 200×; d – HE, 400×). The focus is too small for a definitive diagnosis of adenocarcinoma, however is highly suspicious due to its morphology.
30 de nov. de 2021 · Atypical small acinar proliferation (ASAP) occurs in approximately 5% of prostate biopsies. Approximately 30–40% of patients with ASAP have biopsy detectable prostate cancer (PCa) within 5 years. Current guidelines recommend a repeat biopsy within 3–6 months after the initial diagnosis. The aim of the present study was to examine the ...
Cores containing a small number of visible acini, or distorted acini, for example, may all be labeled as ASAP. 2 Nevertheless, ASAP is clinically relevant because as many as 40% of men with ASAP are diagnosed with PCa on their first re-biopsy. 1 No clinical variables reliably predict which men with ASAP are at the highest risk; therefore, current guidelines suggest that all patients with a ...
